MLH1 (G168-728)

MLH1 is a mismatch repair protein that is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-MLH1 may be useful in identification of MLH1 protein in variety of normal and neoplastic tissues and identification of loss of MLH1 in tumors with MSI genotype.1-8 Anti-MLH1 is best utilized in an IHC panel that includes anti-MSH6, anti-MSH2, and anti-PMS2.