MSH6 (SP93)

MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-MSH6 may be useful in identification of MSH6 protein in variety of normal and neoplastic tissues and identification of loss of MSH6 in tumors with MSI genotype.1-6 Anti-MSH6 is best utilized in an IHC panel that includes anti-MLH1, anti-MSH2, and anti-PMS2.