p53 (SP5)

Anti-p53 tumor suppressor protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild type p53, although significant accumulation of the mutant form of p53 protein due to longer half-life is the basis for the test using the IHC technique.6 Quantitation of nuclear staining with this antibody has been shown to be a factor in breast carcinoma 2-5, lung carcinoma 8, colorectal 7 carcinoma, urothelial carcinoma, and ependymoma9. p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.1