Thyroid Peroxidase (EP159)

Thyroid peroxidase (TPO) is a thyroid-specific enzyme involved in the synthesis of thyroid hormone. TPO can be detected in formalin-fixed, paraffin-embedded tissues of normal thyroid, thyroid carcinoma of papillary and follicular type.1-3 Depending on different series of studies, the sensitivity of TPO for carcinoma of the thyroid has been reported between 44% and 100%, while specificity ranges between 68% and 100%.1-3 Studies indicate that anti-thyroid peroxidase, anti-HBME-1, anti-galectin-3, and anti-CK19, together may form a useful immunohistochemical panel for identification of thyroid carcinoma of papillary and follicular types.1-4