BCL6 (GI191E/A8)

BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein. Antibodies to this protein stain the germinal center cells (benign and malignant) in lymphoid follicles, and interfollicular malignant cells in follicular lymphoma, diffuse large B-cell lymphomas, and Burkitt lymphoma, as well as the majority of tumor cells in nodular lymphocyte predominant Hodgkin lymphoma. 1-3 Anti-BCL6 rarely stains mantle cell lymphoma and mucosa associated lymphoid tissue (MALT) lymphoma.2 BCL6 expression is seen in approximately 68% of ALK+ anaplastic large cell lymphomas (ALCL) and 28% of ALK- ALCL, NK/T-cell lymphoma (27%), peripheral T-cell lymphoma, NOS (8.6%), and T-lymphoblastic lymphoma (9.1%).4 BCL6 expression can also be observed in angioimmunoblastic T-cell lymphoma (66%-96%).5

BCL6 is protected by U.S. patents 6,174,997 and 6,783,94 (Cancer Genetics, Inc.)