CD5 (EP77)

Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma.1,2 CD5 aberrant expression is useful in identification of mature T-cell neoplasms.3,4,5 Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23.1,3 Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies.1,6 In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.1,2