Cytokeratin 20 (Ks20.8)

This antibody reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells. Anti-Cytokeratin 20 is useful in the differentiation of specific types of simple epithelial cells of the urinary tract as well as normal and malignantly transformed epithelia. Studies have identified the presence of Cytokeratin 20 in adenocarcinomas of the colon, stomach, pancreas and biliary system. Additionally, mucinous ovarian tumors, transitional-cell and Merkel cell carcinomas have shown reactivity. In contrast, squamous cell carcinomas and adenocarcinomas of the breast, lung and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas are non-reactive.