Microphthalmia Transcription Factor (MiTF) (C5/D5)

Microphthalmia (MiTF) is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of MiTF exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma, and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).