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PMS2 (EPR3947)

PMS2 is a mismatch repair protein that is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. Anti-PMS2 may be useful in identification of PMS2 protein in variety of normal and neoplastic tissues and identification of loss of MLH1 in tumors with MSI genotype.1-7 Anti-PMS2 is best utilized in an IHC panel that includes anti-MSH6, anti-MSH2, and anti-MLH1.